14. Bills Beat the Minnesota Vikings
The Minnesota Vikings were considered by some as Super Bowl favorites coming into the 2018 season, but those high hopes were squashed early in the season when they lost to the lowly Buffalo Bills.
Rookie quarterback Josh Allen rushed for two touchdowns, hurdled a linebacker and got the first win of his NFL career. What makes this upset even crazier is the fact that Minnesota got blown out to the tune of a 27-6 score.